Sickle cell crisis

From IDWiki

Etiology

  • Vasoocclusive
  • Hemolytic
  • Aplastic (Parvovirus)
  • Splenic sequestration (only before asplenia)

Pain crisis

Acute stroke

  • Monitor, IV, O2 to maintain > 95%
  • Aspirin, but in general not anticoagulation or thrombolysis
  • IV hydration at 1.25-1.5 times maintenance
  • Transfuse to Hb > 100 g/L
  • Then, exchange transfusion to decrease HbS concentration to below 20%