Ribociclib
From IDWiki
- Small molecule inhibitor of cyclin-dependent kinases 4 and 6 (CKD 4/6)
- Used in conjunction with an aromatase inhibitor for treatment of HR-positive HER2-negative stage II to III breast cancer
- Causes QTc prolongation and may interact with drugs involving the CYP 3A4 pathway
- Can cause cytopenias, including anemia, leukopenia, lymphopenia, neutropenia, and thrombocytopenia
- Includes febrile neutropenia, though less often than traditional chemotherapy
- Causes nausea, vomiting, constipation, diarrhea, stomatitis, and peripheral edema
- Common ALT and GGT increases and rare serious hepatotoxicity
- Hypoglycemia, hypokalemia, hypocalcemia, hypophosphatemia
- Rash, pruritus, alpecia
- Rare pulmonary embolism
