Recurrent pregnancy loss
From IDWiki
Definition
- Three or more consecutive loses at less than 20 weeks gestation
- Primary (worse prognosis) or secondary (better prognosis)
Etiology
- Genetic/chromosomal
- Trisomies
- Turner syndrome
- Translocations
- Uterine abnormalities
- Septate uterus (90%)
- Bicornate uterus
- Didelphic uterus
- Asherman syndrome
- T-shaped uterus (DES exposure)
- Autoimmune
- Anti-phospholipid antibody syndrome
- Autoimmune thyroid disorder
- Hormonal
- Literal phase defect
- ?Hypothyroidism
- ?Diabetes
- Thrombophlebitis
- Factor V Leiden
- Infection
Risk factors
- Maternal age
Management
- If negative workup, progesterone may be helpful
