Recurrent pregnancy loss

From IDWiki

Definition

  • Three or more consecutive loses at less than 20 weeks gestation
  • Primary (worse prognosis) or secondary (better prognosis)

Etiology

  • Genetic/chromosomal
    • Trisomies
    • Turner syndrome
    • Translocations
  • Uterine abnormalities
    • Septate uterus (90%)
    • Bicornate uterus
    • Didelphic uterus
    • Asherman syndrome
    • T-shaped uterus (DES exposure)
  • Autoimmune
    • Anti-phospholipid antibody syndrome
    • Autoimmune thyroid disorder
  • Hormonal
    • Literal phase defect
    • ?Hypothyroidism
    • ?Diabetes
  • Thrombophlebitis
    • Factor V Leiden
  • Infection

Risk factors

  • Maternal age

Management

  • If negative workup, progesterone may be helpful