Progressive outer retinal necrosis

From IDWiki

Background

Microbiology

Epidemiology

  • Most closely associated with advanced HIV (typically with CD4 counts less than 50-100)

Clinical Manifestions

  • Rapidly progressing necrosis of the outer retina, in an immunocompromised patient
  • 22% have past medical history of cutaneous zoster, half of which had it in a V1 distribution
  • May have concurrent cutaneous or central nervous system involvement
  • May appear similar to central retinal arterial occlusion

Prognosis

  • Poor, which most patients becoming blind despite treatment
  • Vision is better if they get intravitreal injections

Management