- Family of double-stranded DNA viruses
- Includes the following genera:
- Orthopoxvirus, including vaccinia, variola, mpox, cowpox
- Parapoxvirus, including Orf, paravaccinia
- Molluscipoxvirus, including Molluscum contagiosum
- Yatapoxvirus, including Tanapox and Yaba monkey tumor virus
