Nirmatrelvir-ritonavir

From IDWiki
(Redirected from Paxlovid)

Dosing

  • COVID-19: Nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days, started within 5 days of symptom onset

Renal Dosing

  • eGFR ≥60 mL/min: no adjustment
  • eGFR 30-59 mL/min: 150 mg/100 mg p.o. bid
  • eGFR <30 mL/min: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days
  • Dialysis: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days, given after dialysis on dialysis days

Hepatic Dosing