Parkinson-plus syndrome

• Group of neurodegenerative diseases similar to Parkinson disease

	Lewy-body disease	Multiple system atrophy	Corticobasal degeneration	Progressive supranuclear palsy
Epidemiology	Common; 30% of all dementia cases	2 to 5 cases per 100,000, mean onset 54 years	5 to 7 per 100,000, mean onset early 60s	3 to 7 per 100,000
Clinical manifestations	Deficits in attention, cognition, visuospatial function, with visual hallucinations and sleep movement disorders, falls, autonomic dysfunction	Akinetic-rigid parkinsonism with cerebellar ataxia, autonomic failure, urogenital dysfunction, and pyramidal signs	Asymmetric movement disorder with akinesia and rigidity, myoclonus, dystonia, apraxia	Gait dysfunction with frequent falls, and a supranuclear palsy (unable to move eyes vertically), axial rigidity