Background
- Class of analgesic medications that act primarily on the μ-opioid receptor
Morphine Milligram Equivalent Dose
Fentanyl
| Fentanyl mcg/h
|
MME
|
| 25
|
60-134
|
| 37
|
135-179
|
| 50
|
180-224
|
| 62
|
225-269
|
| 75
|
270-314
|
| 87
|
315-359
|
| 100
|
360-404
|
- IV is essentially twice as strong as PO
Safety
Adverse Events
|
|
Common
|
Occasional
|
Rare
|
| Gastrointestinal
|
nausea, vomiting, constipation
|
delayed gastric emptying
|
biliary coli
|
| Neurological
|
sedation, drowsiness, cognitive dysfunction
|
hallucinations, mood disturbance, anxiety, myoclonus
|
delirium, seizure, addiction
|
| Respiratory
|
inhibition of cough reflex
|
dry mouth, bronchospasm
|
respiratory depression, non-cardiac pulmonary edema
|
| Others
|
miosis
|
pruritus, muscle rigidity
|
hyperalgesia, allodynia, tolerance, physical dependence
|
