Neonatal HCV

From IDWiki

Background

Epidemiology

  • About 5% risk of vertical transmission, though higher if coinfected with HIV
    • About half are transmitted antepartum and half intrapartum

Clinical Manifestations

  • Asymptomatic, usually for decades, before slowly progressive liver disease

Management

Perinatal Exposure

  • Not urgent, as it is a chronic illness that may not manifest for decades
  • Serology to be done at 12-18 months for diagnosis
  • If significant anxiety, can send HCV-PCR at 3 to 6 months
    • 25-30% will spontaneous clear it
    • Still need serology at 12-18 months, and repeat PCR around 18 months