Background
- Also called Wermer syndrome
Clinical Manifestations
- 3 P's: parathyroid, pancreas, and pituitary
- Parathyroid
- Primary hyperparathyroidism in 80-95% of cases, leading to hypercalcemia
- Often the presenting complaint
- Pancreas:
- Endocrine tumours of the pancreas, including gastrinomas (causing Zollinger-Ellison syndrome) and insulinomas (causing hypoglycemia)
- Often metastatic by the time of diagnosis
- Pituitary
- Prolactinoma is most common,
- Can also present with growth-hormone-producing adenomas (causing acromegaly)
