Letermovir

From IDWiki

Background

Mechanism of Action

  • Antiviral that targets subunit 2 of the viral terminase complex (UL56) in cytomegalovirus

Spectrum of Activity

Dosing

  • Letermovir 480 mg IV/PO q24h, infused over 1 hour
  • If concomitant cyclosporine, decrease dose to 240 mg IV/PO q24h

Renal Dosing

  • No dose adjustment needed as long as CrCl >10 mL/min

Safety

Adverse Drug Reaction

  • Nausea, vomiting, diarrhea, cough, headache, peripheral edema

Drug-Drug Interactions