Lambert-Eaton myasthenic syndrome

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(Redirected from LEMS)

Background

  • Paraneoplastic syndrome of weakness that is associated primarily with small cell lung cancer, other solid cancers, or lymphoproliferative diseases
  • Can be non-paraneoplastic (primary autoimmune)
  • Pathophysiology is decreased acetylcholine release from the presynaptic nerves

Clinical Manifestations

  • Slowly progressive proximal muscle weakness without significant atrophy
  • Legs often more than arms
  • Recovery of lost DTRs with exercise or muscle activation (postexercise/postactivation facilitation)
  • Autonomic dysfunction can include dry mouth, slow pupillary light reflex, and erectile dysfunction
  • Can affect cranial nerves
  • Can cause respiratory failure late in the course