Ribociclib

• Small molecule inhibitor of cyclin-dependent kinases 4 and 6 (CKD 4/6)
• Used in conjunction with an aromatase inhibitor for treatment of HR-positive HER2-negative stage II to III breast cancer
• Causes QTc prolongation and may interact with drugs involving the CYP 3A4 pathway
• Can cause cytopenias, including anemia, leukopenia, lymphopenia, neutropenia, and thrombocytopenia
  • Includes febrile neutropenia, though less often than traditional chemotherapy
• Causes nausea, vomiting, constipation, diarrhea, stomatitis, and peripheral edema
• Common ALT and GGT increases and rare serious hepatotoxicity
• Hypoglycemia, hypokalemia, hypocalcemia, hypophosphatemia
• Rash, pruritus, alpecia
• Rare pulmonary embolism