Isopropanol toxicity
From IDWiki
Summary
Definition
- Also known as isopropyl alcohol, or rubbing alcohol
Pathophysiology
- The alcohol is metabolized by alcohol dehydrogenase to acetone, causing ketosis and an osmolar gap, but not an elevated anion gap
Clinical Manifestations
- CNS depression
- Acetone-fruity breath
- Shock, pulmonary edema, hemorrhagic tracheobronchitis
Investigations
- Glucose, to rule out hypoglycemia as a cause of CNS depression
- Acetaminophen and aspirin levels for coingestion
- ECG for QTc
- Osmolar gap, will be high
- Electrolytes, creatinine, urea
- Urea measures as elevated with isopropyl alcohol
- Serum isopropyl alcohol and acetone levels
Management
- ABCs, supportive care
- No role for fomepizole or ethanol
