Hematopoeitic malignancy

• Myeloid: Hemocytoblast
  • Myeloid progenitor
    • Megakaryocyte ---> Thrombocyte
    • Reticulocyte ---> Erythrocyte
    • Mast cell
    • Myeloblast
      • Basaophil
      • Neutrophil: CML
      • Eosinophil
      • Monocyte CMML
        • Macrophage
  • Lymphoid precursor
    • Natural killer cell
    • Small lymphocyte
      • T lymphocyte
      • B lymphocyte: CLL
        • Mature LN: NHL, HL
          • Plasma cell: MM
• Non-Hodgkin lymphoma
  • Indolent (years)
  • Aggressive (months)
  • Very aggressive (weeks)
• Plasma cell neoplasms
  • Light chain amyloidosis
    • deposit anywhere
    • conduction problems, macroglossia
  • B-cell proliferation
    • cytopenias, bone damage