Drug reaction with eosinophilia and systemic symptoms

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(Redirected from DRESS)

Background

  • T-cell mediated hypersensitivity reaction

Clinical Manifestations

DRESS Scoring System

  • Developed for RegiSCAR, though I can't seem to find a primary reference

Criteria

Criterion -1 0 1 2 Notes
Fever ≥38.5ºC No/U Yes
Enlarged lymph nodes No/U Yes >1 cm in ≥2 areas
Eosinophilia
—Eosinophils (if WBC ≥4), or 0.7-1.49 ≥1.5
—Eosinophils (if WBC <4) 10-19.9% ≥20%
Atypical lymphocytes No/U Yes
Rash
—Skin rash (%BSA) No/U >50%
—Skin rash suggesting DRESS No U Yes ≥2 of: purpuric lesions (other than legs), infiltration, facial edema, psoriasiform desquamation
—Biopsy suggesting DRESS No Yes/U
Organ involvement
—Liver involvement No/U Yes Maximum score of 2
—Kidney involvement No/U Yes
—Muscle or heart involvement No/U Yes
—Pancreas involvement No/U Yes
—Other organ involvement No/U Yes
Resolution ≥15 days No/U Yes
Exclusion of other causes Yes at least 3 tests were done and negative: HAV, HBV, HCV, ANA, blood cultures, Mycoplasma, Chlamydia

Interpretation

Interpretation Points
Definite ≥6
Probable 4-5
Possible 2-3
Not DRESS ≤1

Further Reading