Cronkhite-Canada syndrome

Clinical Manifestations

• Diarrhea, alopecia, gastrointestinal hamartomatous plypopsis, onychodystrophy, hyperpigmentation

Investigations

• Often have positive ANA and elevated IgG4 levels

Differential Diagnosis

• Juvenile polyposis
• Cowden disease
• Bannayan-Riley-Ruvalcaba syndrome
• Peutz-Jeghers syndrome