Chronic inflammatory demyelinating polyradiculoneuropathy
From IDWiki
Background
- Rare immune-mediated demyelinating polyneuropathy
Clinical Manifestations
- Progressive or relapsing symmetric muscle weakness
- Can be proximal or distal, upper or lower extremities
- At least 8 weeks
- Absent or decreased deep tendon reflexes
- Variants:
- Distal CIDP: distal sensory loss and muscle weakness predominantly in lower limbs
- Multifocal CIDP: sensory loss and muscle weakness in a multifocal pattern, usually asymmetric, upper limb predominant, in more than one limb
- Focal CIDP: sensory loss and muscle weakness in only one limb
- Motor CIDP: motor symptoms and signs without sensory involvement
- Sensory CIDP: sensory symptoms and signs without motor involvement
Diagnostic Criteria
| Criterion | Typical | Distal | Multifocal/Focal | Motor | Sensory |
|---|---|---|---|---|---|
| Clinical Criteria | |||||
| Weakness | symmetric in 4 limbs, proximal and distal | Predominantly distal lower limbs | 2 or more limbs (multifocal) or 1 limb (focal) | symmetric in 4 limbs, proximal and distal | none |
| Sensory disturbance | in 2 or more limbs | in 2 or more limbs | in distribution of affected limbs | none | symmetric in 4 limbs |
| Electrodiagnostic Criteria | |||||
| Motor conduction criteria | + | + | + | + | normal |
| Sensory conduction abnormalities | + | + | + | normal | |
| Sensory conduction criteria | − | − | − | − | |
Further Reading
- EAN/PNS guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force—Second revision. Eur J Neurol. 2021 ;28(11):3556-3583. doi: 10.1111/ene.14959.
