Baricitinib
From IDWiki
Background
- Oral JAK inhibitor
- Indications include COVID-19
Dosing
- Severe or critical COVID-19: 4 mg p.o. daily for 14 days, or until hospital discharge
Renal Dosing
- eGFR 30-60 mL/min: 2 mg p.o. daily
- eGFR 15-30 mL/min: 2 mg p.o. every other day, or 1 mg p.o. daily
- eGFR less than 15 mL/min: not recommended
- Dialysis: not recommended
Safety
Contraindications
- Contraindications and relative contraindications include hypersensitivity, co-existing infection, immunosuppression, increase liver enzymes
Adverse Reactions
- Increased risk of infections
- Venous thrombosis and thromboembolism
