Rilonacept

• IL-1 inhibitor
• Dimeric fusion protein with the extracellular component of IL-1 receptor fused to the Fc portion of IgG1
  • Binds circulating IL-1α and IL-1β
• Indications include cryopyrin-associated periodic syndromes (familial cold autoinflammatory syndrome and Muckle-Wells syndrome)
• Infectious complications include most commonly upper respiratory tract infections, but also pneumococcus, meningitis, NTM, and bronchitis