Anticoagulation

Anticoagulants

• Parenteral
  • Thrombin inhibitors
    • Bivalirudin
    • Argatroban
    • irudin
  • Thrombin/X inhibitors
    • Heparin
    • LMWH
      • Enoxaparin
      • Dalteparin
  • Factor Xa inhibitors
    • Fondaparinux
• Oral
  • Thrombin inhibitors
    • Dabigatran
  • Factor Xa inhibitors
    • Rivaroxaban
    • Apixaban
    • Edoxaban
  • Vitamin K antagonists
    • Warfarin

VTE in obesity

• Recommend against DOACs in obese patient BMI>40 or weight>120kg dur to lack of clinical data
• Can monitor drug-sepciic peak and trough level
• Can use warfarin instead

VTE in cancer

• Favour low-molecular weight heparin
• Based on CLOT trial